内科学糖尿病(8年制)
64页1、Diabetes Mellitus,Definition, Epidemiology, Classification, Diagnostic criteria Etiology and pathogenesis Pathophysiology Clinical presentation Lab test Treatment DKA and NHDC,Stage I: description of the signs of diabetes recognition diabetes mellitus: polyuria, urine is sweet,Stage II: diabetes is associated with pancreas -find of insulin,Jan. 1922 Dr. Banting extract the insulin from pig pancreas and applied for the diabetic patients Father of insulin 14th November World Diabetes Day,Stage III
2、: defects in insulin action -insulin resistance “a group of metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both . The chronic hyperglycemia is associated with long-term damage, dysfunction and failure of various organs, especially the eyes, kidney, nerves, heart and blood vessels.”,Stage IV: diabetes can involve the eyes, kidneys, nerves and blood vessels,Diabetic retinopathy,Diabetic nephropathy,Diabetic foot,microangiopathy,macro
3、angiopathy,Cerebral vessel,Coronal vessel,Peripheral vessel,World Health Organization/International Diabetes Federation, 1999. Diabetes Care 2001; 24 (Suppl 1):S5S20.,Definition Diabetes mellitus is a heterogeneous primary disorder of carbohydrate metabolism with multiple etiologic factors that generally involve absolute or relative insulin deficiency or both. All causes of diabetes ultimately lead to hyperglycemia, and it can causes the late complications involving the eyes, kidneys, nerves and
4、 blood vessels.,Environmental-Genetic interactions,Absolute or relative insulin deficiency,Disorder of carbohydrate, protein and fat metabolism,hyperglycemia,Complications involving the eyes,kidneys,nerves and blood vessels,病因,发病机制,病理生理,共同特征,最终结局,Epidemiology,Global prevalence of diabetes,1 2 3 4 5 6 7 8 9 10 Total,印度 中国 美国 俄联邦 日本 巴西 印度尼西亚 巴基斯坦 墨西哥 Ukraine 所有其他国家,19.4 16.0 13.9 8.9 6.3 4.9 4.5 4.3 3.8 3.6 49.7 135.3,印度 中国 美国 巴基斯坦 印度尼西亚 俄联邦 墨西哥 巴西 埃及 日本 所有其他国家,57.2 37.6 21.9 14.5 12.4 12.2 11.7 1
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