缺氧病理生理学ppt课件
56页1、Chapter 6 Hypoxia,绝食,14天,绝水,7天,绝O2,数分钟,O2是人体的第一生命物质。,摄取,携带,运输,利用,Concept,Hypoxia can be defined as deficiency in either the delivery or the utilization of oxygen at the tissue level, which can lead to changes in function, metabolism and even structure of the body.,或,机能、代谢、形态结构异常,Parameters of blood oxygen,1. partial pressure of oxygen, PO2,物理溶解于血浆中的氧所产生的张力,PO2 is the tension produced by oxygen molecules physically dissolved in plasma.,Partial pressure of inspired oxygen (吸入气氧分压, PiO2 ) Partial p
2、ressure of oxygen in the alveoli (肺泡内氧分压,PAO2 ),Acting factor,PaO2: 100 mmHg ( 13.3kPa ) PvO2: 40 mmHg ( 5.3kPa ),Normal value,2. oxygen binding capacity, CO2max,100ml血液中Hb所能结合氧的最大毫升数,Maximal amount of oxygen that can be potentially bound by the haemoglobin is called oxygen binding capacity of haemoglobin.,Hb concentration and quality,Acting factor,Normal value : 20 ml%,100ml血液实际所含的氧量,3. oxygen content, CO2,The total oxygen content of blood includes oxygen that is bound to haemoglobin an physica
3、lly dissolved in plasma.,PaO2; CO2 max,In artery:19ml%; In vein:14ml%,Acting factor,Normal value,4. oxygen saturation, SO2,SO2 is the percentage of haemoglobin present as oxyhaemoglobin.,In artery :9395 In vein :7075,Acting factor: PaO2,Normal value,5. arteriovenous blood oxygen difference , AVDO2,动脉血与静脉血氧含量之差,19ml/dl,14ml/dl,5ml/dl,Normal value:5ml%,utilization of oxygen in the tissue,Acting factor:,Section 1 Classification, Etiology & Pathogenesis, Hypotonic hypoxia(低张性缺氧),各种原因使PaO2,以致血氧含量 ,组织
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