Oxy-16_hedgehog活性的拮抗剂_596-94-1_Apexbio.pdf
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产品名: Oxy-16 修订日期: 6/30/2016 产品说明书产品说明书 化学性质化学性质 产品名产品名: Oxy-16 //struct// Cas No.: 596-94-1 分子量分子量: 418.7 分子式分子式: C27H46O3 别名别名: 20(R),22(R)-dihydroxy Cholesterol 化学名化学名: cholest-5-ene-3b,20,22R-triol SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])C2CC[C@@]4(C)[C@@]3 ([H])CC[C@]4([H])[C@@](C)(O)[C@H](O)CCC(C)C 溶解性溶解性: Soluble in DMSO 储存条件储存条件: Store at -20°C 一般建议一般建议: For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. 运输条件运输条件: Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 生物活性生物活性 靶点靶点 : Stem Cell 信号通路信号通路: Hedgehog 产品描述产品描述: Oxy-16 is an antagonist of hedgehog activity. Naturally occurring oxysterols that are products of cholesterol oxidation can stimulate the hedgehog (Hh) signaling pathway related to cardiovascular disease and bone formation. Activation of Hh signaling modulates inflammatory responses to additional atherogenic factors including lesion-producing macrophages and enable osteoblast differentiation, which is dependent on the target cell. In vitro: Oxysterols have been shown to be associated with immunosuppression, apoptosis, atherosclerosis, inflammation, and cholesterol turnover. Other studies aslo indicated that oxysterols were Hedgehog (Hh) signaling pathway activators and had potent osteoinductive properties. Oxy-16, an oxysterol, was identified as a cell permeable oxygenated derivative of cholesterol that might be the end product or intermediate of the cholesterol excretion pathways. Oxy-16 is currently used as a transport form for cholesterol across the blood brain barrier and membranes. The osteogenic differentiation caused by Oxy-16 was cinsidered to be mediated via a Wnt signaling-related, Dkk-1-inhibitable mechanism [1]. In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted. 参考文献参考文献: 特别声明特别声明 产品仅用于研究，产品仅用于研究， 不针对患者销售，望谅解。
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