左亚叶酸钙 MSDS.pdf

Sigma - 47612 Sigma-Aldrich Corporation www.sigma- Page 1 of 5 SIGMA-ALDRICH Material Safety Data Sheet Version 3.0 Revision Date 08/23/2008 Print Date 10/14/2010 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Folinic acid calcium salt hydrate Product Number : 47612 Brand : Sigma Company : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +18003255832 Fax : +18003255052 Emergency Phone # : (314) 776-6555 2. COMPOSITION/INFORMATION ON INGREDIENTS Formula : C20H21CaN7O7·xH2O Molecular Weight : 511.50 g/mol CAS-No. EC-No. Index-No. Concentration Calcium folinate hydrate 1492-18-8 216-082-8 - - 3. HAZARDS IDENTIFICATION Emergency Overview OSHA Hazards Irritant HMIS Classification Health Hazard: 2 Flammability: 0 Physical hazards: 0 NFPA Rating Health Hazard: 2 Fire: 0 Reactivity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Skin May be harmful if absorbed through skin. Causes skin irritation. Eyes Causes eye irritation. Ingestion May be harmful if swallowed. 4. FIRST AID MEASURES Sigma - 47612 Sigma-Aldrich Corporation www.sigma- Page 2 of 5 General advice Move out of dangerous area.Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5. FIRE-FIGHTING MEASURES Flammable properties Flash point no data available Ignition temperature no data available Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Environmental precautions Do not let product enter drains. Methods for cleaning up Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal. 7. HANDLING AND STORAGE Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Storage Keep container tightly closed in a dry and well-ventilated place. hygroscopic Light sensitive. Store under inert gas. Air sensitive. Keep in a dry place. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Contains no substances with occupational exposure limit values. Personal protective equipment Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Sigma - 47612 Sigma-Aldrich Corporation www.sigma- Page 3 of 5 Eye protection Safety glasses Skin and body protection Choose body protection according to the amount and concentration of the dangerous substance at the work place. Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Form powder Colour beige Odour odourless Safety data pH 6.8 - 8.0 at 25 g/l Melting point no data available Boiling point no data available Flash point no data available Ignition temperature no data available Lower explosion limit no data available Upper explosion limit no data available Water solubility 4 g/l 10. STABILITY AND REACTIVITY Storage stability Stable under recommended storage conditions. Materials to avoid Strong oxidizing agents Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx) Thermal decomposition 240 - 250 °C (464 - 482 °F) 11. TOXICOLOGICAL INFORMATION Acute toxicity LD50 Oral - rat - > 8,000 mg/kg Irritation and corrosion no data available Sensitisation May produce an allergic reaction. Sigma - 47612 Sigma-Aldrich Corporation www.sigma- Page 4 of 5 Chronic exposure IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. NTP: No component of this product present at levels greater 。