危险性分析的原则及其在食品安全中的应用(1)精编版
41页1、【WORKSHOP ON AGRO-FOOD SAFETY ISSUES 2002.10.9-11】General Principle 欧洲污染水平/欧洲膳食结构,摄入量 人群危险度 (ng/人/天) (个肝癌/年/10万人) 限量20 g/kg 19 0.0041 (0.0006-0.01) 限量10 g/kg 18 0.0039 (0.0006-0.01) 相差 2个肝癌/年/亿人,29,例2. HBsAg() 25%; 中国污染水平/远东膳食结构,摄入量 人群危险度 (ng/人/天) (个肝癌/年/10万人) 限量20 g/kg 125 0.17 (0.03-0.3) 限量10 g/kg 103 0.14 (0.02-0.3) 相差 300个肝癌/年/亿人 *1990-92年全国肝癌死亡率20/10万,30,CCFH ACTIVITIES,32nd CCFH (1999) Decided to proceed in MRA on the basis of pathogen/commodity combinations;Elaborated and agreed on tentat
2、ive priority list of pathogen / commodity combinations 决定对病原食品组合进行微生物危险性评估,并提出暂定优先组合,31,CCFH Drafting groups食品卫生法典委员会起草工作组,L. monocytogenes in ready-to-eat food(Germany) 即食食品中的单增李斯特菌 Salmonella spp. in poultry (Sweden) 禽肉中的沙门氏菌 Campylobacter spp. in poultry (Netherlands) 禽肉中的空肠弯曲菌 Vibrio spp. in seafood(United States) 海产品中的副溶血性弧菌 Enterohemorrhagic E. coli in meat(United States) 肉食品中的出血性大肠杆菌,32,Why RA is needed in China?我国为什么要进行危险性分析?,WTO CODEX / GB FOOD INDUSTRY FOOD SAFETY CONTROL Government Co
3、nsumers HEALTH PROTECTION Life quality knowledge,国际贸易 食品法典 / 国家标准体系 食品工业 食品安全控制 政府 消费者 保护消费者健康 生活质量的提高 对食品安全知识的需求,33,Case in China The Control of the Deteriorated Sugarcane Food Poisoning,Fresh sugarcane grown in southern area of China Shipped, stored and sold through the winter season in the northern parts of China Contaminated sugarcane could cause fatal food poisoning when sold in the next spring,34,Sugarcane poisoning,The first outbreak of unknown causes sugarcane poisoning occurred in Henan
4、 Province in 1972 From 1972 to 1989: No. of outbreak: 217 No. of cases: 884 No. of deaths: 88 Average fatality: 10% Identified as a priority to assess and control by MOH,35,Etiology and risk assessment,Etiology and causes study were been carried out by the Chinese Academy of Preventive Medicine in 1980s Arthrinium spp. was the pathogenic fungus; 3-nitropropionic acid (3-NPA) produced by A. spp. was proved to be the causative compound Assessment was made according to case-based studies, epidemiol
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