年产2000万支250ml糖浆剂生产车间工艺设计.docx

北京理工大学珠海学院北京理工大学珠海学院布 洛 芬 糖 浆 剂 工 艺 设 计题 目： 年产 2000 万支 250ml 糖浆剂 生产车间工艺设计 学生姓名： 陈塨慧、苏泽鹏、萧志乐 蔡权、冯宇 学 院： 化工与材料学院 专业班级： 12 应用化学 2 班 2015 年 10 月北京理工大学珠海学院 16 届本科生课程设计I年产年产 20002000 万支万支 250ml250ml 糖浆剂生产车间工艺设计糖浆剂生产车间工艺设计摘要摘要依据GMP的思想，为布洛芬糖浆生产提供合理的生产工艺与车间布局根据糖浆制剂车间设计的原则和规定科学有效地设计出年产2千万支250ml布洛芬糖浆的生产车间对处方的设计、糖浆制剂工艺流程的设计以及物料衡算、工艺设备选型、车间设计和成本估算等进行了详细的研究和分析，并最终设计出有效可行的年产2千万支250ml布洛芬糖浆生产车间工艺本设计严格遵守GMP规定，符合环保、经济、安全、技术等方面的要求关键词：关键词：GMP；布洛芬糖浆；生产工艺；车间布局北京理工大学珠海学院 16 届本科生课程设计IAn annual output of 20 million-250ml ibuprofen syrup process design workshopAbstractAccording to the thought of GMP, provide the production process and workshop layoutreasonable for ibuprofen syrup production.According to the principles and provisions of the syrup preparation workshop design science effectively design an annual output of 20 million pieces of 250ml of ibuprofen syrup production workshop.The formulation design, injection process design and the material balance, process equipment selection, workshop design and cost estimation of the detailed research and analysis. And the final design of an annual output of 20000000 effective 250ml ibuprofen syrup production process.This designstrictly abide by the provisions of GMP, with the environmental protection, economy, safety,technology and other aspects of the request. Keywords : GMP；ibuprofen syrup；production process；workshop layout北京理工大学珠海学院 16 届本科生课程设计I目录目录1 前言 ...........................................................................11.1 布洛芬糖浆剂的介绍.......................................................11.1.1 布洛芬的适应症 ....................................................11.1.2 布洛芬的介绍 ......................................................11.1.3 布洛芬的主要剂型 ..................................................21.1.4 糖浆剂介绍 ........................................................21.1.5 糖浆剂的特点 ......................................................21.1.6 糖浆剂剂的分类 ....................................................21.1.7 糖浆剂的规格和质量................................................31.1.8 糖浆剂在制备与贮藏过程中易出现的问题 ..............................32 制剂规格、处方研究 .............................................................42.1 制剂规格设计.............................................................42.2 实验室制法...............................................................52.3 处方分析.................................................................52.3.1 主药布洛芬的处方分析 ..............................................52.3.2 粘度控制剂处方分析 ................................................62.3.3 甜味剂 ............................................................62.3.4 悬浮剂 ............................................................6北京理工大学珠海学院 16 届本科生课程设计II2.3.5 乳化剂 ............................................................62.3.6 PH 控制剂 .........................................................63 工艺流程设计 ...................................................................73.1 工艺流程图...............................................................74 物料衡算 .......................................................................74.1 参数设计.................................................................84.2 原辅料物料衡算...........................................................84.3 各工序物料进出计算......................................................114.4 包装材料物料衡算........................................................124.4.1 内包材料物料衡算 .................................................124.4.2 外包材料物料衡算 .................................................124.4.3 标签说明书物料衡算 ...............................................134.4.4 物料衡算总表 .....................................................135 主要生产设备选型 ..............................................................145.1 纯水设备选型............................................................145.2 溶糖锅设备选型..........................................................155.3 配液罐设备选型..........................................................155.4 过滤设备选型............................................................165.5 泵设备选型..............................................................165.6 ph 计设备选型...........................................................175.7 封口机设备选型..........................................................17北京理工大学珠海学院 16 届本科生课程设计III5.8 激光打码机设备选型......................................................175.9 灯检工作设备选型........................................................185.10 洗瓶设备选型...........................................................185.11 灭菌设备选型...........................................................195.11 印字贴标设备选型.......................................................195.12 理瓶设备选型...........................................................206 生产工艺流程概述 ..............................................................206.1 称量与筛分..............................................................206.2 配料....................................................................216.3 过滤....................................................................226.5 灌封与灭菌............................。