抗氧化剂让你延年益寿.ppt

Click to edit Master title style,,Click to edit Master text styles,,Second level,,Third level,,Fourth level,,Fifth level,,,,*,Click to edit Master title style,,Click to edit Master text styles,,Second level,,Third level,,Fourth level,,Fifth level,,,,*,抗氧化劑,：,讓你延年益壽,Antioxidants: add life to your years,,,,,NuSkin presentation,,Taiwan,,November 3, 2007,Prof. Lester Packer,,,1,,,百歲人瑞,Centenarian,,2,,0,20,40,60,80,100,0,20,40,60,80,100,120,長壽人口增加後之存活率,%,,,Survival if % reduction in mortality at all ages occurs again,,1985,存活率,1985 Survival,1900,存活率,1900 Survival,,存活率,,% OF POPULATION SURVIVING,,年齡分布,,Chronological Age,健康長壽的趨勢,Toward Healthy Aging,T.B.L. Kirkwood in Longevity: To the limits and Beyond. Ed. By J.M. Robine et.al.,,Published by Springer: Heidelberg, 1997.,,3,,0,20,40,60,80,100,Colon,Cancer,Stroke,Coronary,Disease,Diabetes,,Type 2,改變生活型態以預防疾病的發生,,Diseases Avoidable by a Change in Lifestyle,Walter Willett Science 296, 695-,698: 2002,,-,減少百分比,,Percent avoidable,結腸癌,中風,冠狀動脈疾病,第二型糖尿病,,4,,,前列腺癌比例,上海人,,Shanghai,born,,Chinese,1.7,中國人,(,居住美國,< 5,年,),,China born Chinese,,(live in US < 5 yrs),1.8,中國人,(,居住美國,> 5,年,),,China born Chinese,,,(live in US > 5 yrs),23,在美國出生的中國人,US born Chinese,37,美國出生的高加索人,US born Caucasian,58,US,China,,亞洲國家,,Asian,,Countries,,西方國家,,Western,,Countries,Int.J. Cancer (2000) 85:60-7,,Courtesy Emily Ho,,5,,氧化壓力,,Oxidative Stress,自由基造成氧化壓力,,Free radicals cause oxidative stress,,,導致組織壞死、老化及疾病的發生,Leads to tissue damage, aging and disease,,,6,,,維生素,C,及,E,,Vitamins C and E,,多酚類,(,類黃酮,),,Polyphenols,(,Flavonoids,),),,硫氫基,Thiols,：,麩胱甘肽,,Glutathione,,,硫辛酸,Lipoic,Acid,,,輔酵素,Q10,,Co-enzyme Q,抗氧化劑,,Antioxidants,類胡蘿蔔素,,Carotenoids,氧化還原循環,,Redox cycling,清除自由基,Radical scavenging,,7,,,8,,,9,,皮膚構造,角質層,表皮層,真皮層,,10,,紅斑,,一種典型的曬傷後發炎反應,,MED,是紅斑的衡量單位。

它是指少量的,UVB,照射,24,小時候後,，,在皮膚產生些微的紅斑現象的評估,11,,,12,,人體角質層中的維生素,E,濃度,α,-,生育醇,γ,-,生育醇,濃度,(pmol),濃度,(pmol),,13,,抗氧化網絡運作模式,,The Antioxidant Network in Membranes,VitE,循環,Vit. E,•,,Cycle,,Q10,循環,,Q,10,H,•,,Cycle,維生素,C,循環,Vit. C,•,,Cycle,脂質自由基,Lipid Free Radicals,,LOO,•,LO,•,類胡蘿蔔素,,Carotenoids,代謝,Metabolism,脂溶性環境,,Fat Soluble,水溶性環境,Water Soluble,水溶性環境,Water Soluble,,氧化代謝,Oxygen,,Metabolism,,14,,蔬果中的類胡蘿蔔素,,Carotenoids in fruits & vegetables,β-,隱黃質,β,-cryptoxanthin,,(,13-20%),葉黃素,Lutein,,(10-20%),α-,胡蘿蔔素,,a-,carotene,,(5-10%),β-,胡蘿蔔素,,b,–,carotene,,(15-30%),玉米黃質,,Zeaxanthin,,(1-5%),菠菜,,,豌豆,,,青豆,,,白豆,,,綠花菜,,,球芽甘藍,,,包心菜,,,無頭甘藍菜,,,奇異果,,,萵苣,,Spinach, Green peas, Green Beans , Lima Beans Broccoli, Brussel sprouts, Cabbage, kale, Kiwi, Lettuce,,,胡蘿蔔,,,南瓜,,,地瓜,,,杏子,,,洋香瓜,,,西瓜,Carrots, Pumpkin, Sweet Potatoes,,,Apricots, Cantaloupe, Watermelon,,,蕃茄,,,紅葡萄柚,,Tomatoes, Pink Grapefruit,人類細胞中的類胡蘿蔔素,,Carotenoids in Human Plasma,蕃茄紅素,Lycopene (20-40%),,15,,拉曼光譜研究,~,利用測量眼睛類胡蘿蔔素含量,，,來診斷老化引起的視網膜黃斑退化現象,,Raman scattering studies are used to measure carotenoids in the Eye and to diagnose age-related macular degeneration,斑點,Macula,葉黃素,&,玉米黃質,,Lutein & Zeoxanthin,Gellermann W, Ermakov IV, McClane RW, Bernstein PS.,,Raman imaging of human macular pigments.,,Optics Letters. 2002;27:833,人類視網膜,視網膜,視神經,,16,,,C. Smidt and D.S. Burke, Nutritional Significance and Measurement of Carotenoids,,Current Topics in Nutraceutical Research,2004,,2,, 79-91,0,20000,40000,60000,0,0.5,1,1.5,2,2.5,3,3.5,4,血清中類胡蘿蔔素總量,Total Serum Carotenoids (,μ,g/ml),Skin Raman Intensity (n = 372),r = 0.84 (p<0.0001),,p<0.01,p<0.01,p<0.01,Std. Error 44,Std. Error 38,Std. Error 61,Std. Error 106,24793,26639,29704,31507,10000,15000,20000,25000,30000,35000,1 or less,2 to 3,4 to 5,6 or more,Courtesy Stephen Poole, Pharmanex,Skin Raman Intensity,,(2005 US data of 209,628 Non-Supplement Users),,,每日食用水果及蔬菜份數,Daily servings of fruits and vegetables,良好的生活型態增進皮膚抗氧化類胡蘿蔔素,,與掃描儀之研究,,,Lifestyle can improve carotenoid antioxidants in skin- Scanner studies,,209,628,位受試者,,從未使用過營養補充品,,結論：每日吃,6,份以上蔬果者，皮膚類胡蘿蔔素指數明顯增加,身體防禦指數,身體防禦指數,,17,,4,毫克葉黃素,4 mg Lutein,¼,杯烹煮過的菠菜,¼ cup of cooked spinach,1,又,1/3,根中型胡蘿蔔 或,¼,杯南瓜,,1 & 1/3 medium carrots or ¼ cup pumpkin,4,毫克,b,-,胡蘿蔔素,,4 mg,b,-Carotene,4,毫克蕃茄紅素,,,4 mg Lycopene,1,顆中型番茄 或,¾,茶匙番茄醬,,1 medium tomato,,or ¾ Tsp tomato paste,營養補充品中的類胡蘿蔔素含量與天然食物的相對份量,Carotenoids in human supplements,equivalent,,to amounts in food (courtesy,KJ Yuem),,18,,食用營養補充品後,，血漿中總類胡蘿蔔素濃度增加,Plasma Total Carotenoid Concentration,,Is increased after Supplementation,時間,,,日,,Time, Day,D1,D15,D29,D43,D57,Plasma Total Carotenoid (,m,g/dL),0,20,40,60,80,100,120,140,160,180,Placebo,對照組,Mixed Car,綜合類胡蘿蔔素,Lutein,,葉黃素,,b,-Carotene,,b,-,胡蘿蔔素,,Lycopene,,蕃茄紅素,,*,,,*,*,,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,*,Significantly different from baseline,,顯著差異,*,p<0.05,Courtesy KJ Yuem, et al.,血漿中總類胡蘿蔔素濃度,(mg/dL),,19,,食用含類胡蘿蔔素的營養補充品在慧星分析法証實,，,可以保護人類淋巴球中的,DNA,免受破壞,,Carotenoid Supplementation protects against DNA Damage in human lymphocytes,,The comet assay,第,57,天,Day 57,第,1,天,Day 1,35,563,位受試者,(Subject # 35563),Courtesy KJ Yuem, et al.,,20,,維生素,A,在健康百歲人瑞體內含量顯著比年輕人高,,Vitamin A levels are increased in healthy centenarians compared to younger subjects,Vitamin A (µM),,100,歲,,Centenarians,< 60,歲,60-79,歲,80-99,歲,153,位義大利百歲人瑞,,153 Italian centenarians, * p < 0.0001,*,*,*,0,1,2,3,4,5,6,Christina Polidori, Eur J Clin Nutr 2007,,,(µM),維生素,A,,21,,,,,酵素,&,蛋白質的誘導物,,,保護抗氧化劑,,,Inducers of enzymes & proteins,,,,needed for antioxidant defense,,人體中類胡蘿蔔素,,,Carotenoids in Humans are,維生素,A,的前驅物,,,環狀碳氫化合物的類胡蘿蔔素,,Vitamin,A precursors,,cyclic hydrocarbon,carotenoids,,清除自由基,Free radical scavengers,,,對抗氧化,,protect against oxidation,,22,,。