8、ABD活性因子与疲劳和运动相关研究.doc

美源康富A.B.D活性因子与疲劳和运动相关研究美源康富ABD活性因子平衡肌肉与免疫系统的竞争过徵运动后各易感冒，这不是因为出汗，吹风受凉而是因为肌肉运动中产生人朵自由基，需要更多谷胱甘肽抗氧化，与免疫系统对谷胱甘肽需求 产生竞争过度训练的运动负往往容易生病ABD活性因了为全身各个组织补充芥胱卄肽，肌肉和免疫系统就不会再去竞争冇限的谷胱廿肽，提升运动 员的免疫力和运动成绩很多北美奥运会运动员都使用美源康富ABD活性因子提高成绩，它的安全性可以通过最严格的运动员药物检查美源康富ABD活性因子排出毒素，抗疲劳疲劳综合症是多种原因引起的，其中一项是慢性中毒美源康富ABD活性因子具有强大的排毒功能，而.R排出的是细胞内沉积已久的重金厲、辐射 物等毒素，从源头上消除慢性疲劳美源康富ABD活性因子中的优质氨基酸是最好的营养来源美源康富ABD活性因子是生物价值最高的蛋白质，其中必需氨基酸的利用率在所有蛋白种类中最高，是优质的氨酸来源，为人体补充高质量营养, 增加所有人尤其是病人的体力和精力1. Competition for Glutathione Precursors between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue SyndromeG. Bounous1, J. Molson2’Former Professor，Department of Surgery，McGill University, and career Investigation of the Medical Research Council of Canada.21994 Quebec Cycling Champion. Road and Time TrialMEDICAL HYPOTHESES (1999) 53(4): 347-349 - 1999 HARCOURT PUBLISHERS LTD. • ARTICLE NO. MEHY. 1998.0780)Summary: The chronic fatigue syndrome (CFS) is typically associated or follows a recognized or presumed infection. Abnormalities of both humoral and cellular immunity have been demonstrated in a substantial proportion of patients with CFS. The most consistent findings are of impaired lymphocyte responses to mitogen. As an antioxidant, glutathione (GSH) is essential for allowing the lymphocyte to express its full potential without being hampered by oxiradical accumulation. Hence, protracted challenge of the immunocytes may lead to cellular GSH depletion. Because GSH is also essential to aerobic muscularcontraction, an undesirable competition for GSH precursors between the immune and muscular systems may develop. It is conceivable that the priority of the immune system for the survival of the host has drawn to this vital area the ever-diminishing GSH precursors, thus depriving the skeletal muscle of adequate GSH precursors to sustain a normal aerobic metabolism resulting in fatigue and eventually myalgia.［研究主题］免疫系统和骨骼肌对谷胱卄肽前驱物的竞争：慢性疲劳综介症的致病机制［研究综述】慢性疲劳综合症与感染典型性相关。

慢性疲劳综合症患者伴随体液和细胞免疫异常现象敁常见的现象是淋巴细胞对抗原的反应下降作为抗轼化剂， 谷胱LT肽是淋巴细胞充分发挥功能的欠键物质，使其不受氧化Pl由基堆积的伤害因此，免疫细胞的过度反应会导致细胞内谷胱U‘肽消粍谷胱U‘肽对 肌肉收缩也很秉要，因此免疫系统和肌沟系统之间会产生对谷胱甘肽前驱物的竞争山于免疫系统缺失谷胱甘肽对人体的影响更加严秉，人体会选择性 剥夺骨骼肌中的谷胱甘肽前驱物供给免疫系统，从而使骨骼肌无法维持正常的有氧代谢，造成疲劳其至疼痛［文献米源】G. Bounous, J. Molson，《医学假说》，1999年53期第4卷347-349页2. The Effect of Supplementation with a Cysteine Donor on Muscular PerformanceLC Lands, MD, PhD’t, VL Grey, PhDft, AA Smountas, BSc*’Division of Respiratory Medicine，tDepartment of Pediatrics，^Department of Biochemistry，McGill University Health Centre-Montreal Childrens Hospital, Montreal, Quebec，CanadaJOURNAL OF APPLIED PHYSIOLOGY, 87: 1381-1385, 1999Abstract: Oxidative stress contributes to muscular fatigue. GSH is the major intracellular antioxidant，the biosynthesis of which is dependent on cysteine availability. We hypothesized that supplementation with a whey-based cysteine donor [ABD Bioactive Cytokines] designed to augment intracellular GSH wouldenhance performance. Twenty healthy young adults (10 men，10 women) were studied presupplementation and 3 mo postsupplementation with either ABD Bioactive Cytokines (20 g/day) or casein placebo. Muscular performance was assessed by whole leg isokinetic cycle testing, measuring peak power and 30-s work capacity. Lymphocyte G3H was used as a marker of tissue G3H. There were no baseline differences (age，ht，wt，%ideal wt, peak power，30-s work capacity). Follow-up data on 18 subjects (9 ABD Bioactive Cytokines, 9 placebo) were analyzed. Both peak power [13 +/- 3.5 (SE) %, P < 0.02] and 30-s work capacity (13 +/• 3.7%, P < 0.03) increased significantly in the ABD Bioactive Cytokines group, with no change (2 +/- 9.0 and 1 +/• 9.3%) in the placebo group. Lymphocyte GSH also increased significantly in the ABD Bioactive Cytokines group (35.5 +/- 11.04%, P < 0.02), with no change in the placebo group (-0.9 +/- 9.6%). This is the first study to demonstrate that prolonged supplementation with a product designed to augment antioxidant defenses resulted in improved volitional performance.［研究主题］补充可提供半胱氨酸的蛋白食品美源康富ABD活性因了对肌肉表现力的影响［研究目的】轼化压力造成肌肉疲劳。

谷胱It肽是首要细胞内抗氣化剂，其生物合成依赖细胞内半胱鉍酸含fi我们使川一种乳清蛋A米源的半胱鉍酸供体(美源康 富ABD活性因子)，来研究提升细胞内谷胱U肽是否能增强肌肉表现力［研究内容】选取20位健座年轻人(10男10女)，随机分为两组，一组每日服用20克ABD活性因子，另一组毎日服用20g酪蛋白安慰剂，服用前和服用3个；J后 对他们进行检测通过检测他们骑自行车肌肉力虽来衡S肌肉表现力，并抽血检验淋巴细胞A的谷胱tf肽含呈服川前，两组的菽准指标无差异［研究结果］三个月后，ABD活性因子组的顶点力(13+/-3.5(SE)%,P<0.02］和30秒活动能力(13+/-3.7%,P<0.03)都明显提升，而安慰剂组没有明显变化 (2+/-9.0andl+/-9.3%)o ABD活性因子组的淋巴细胞谷胱甘肽含量也显著提力了(35.5+/-11.04%,P<0.02)，而安慰剂组没有明显变化(-0.9+/-9.6%)h/IOLUrl} Hso a}xooqduMq.Ea6uex:o%>POM:oas 0coT39lo!F>aJd 0/0 u? eo)ueqoo/GFig. 1 Percent change from baseline In lym phocyte GSH levels (left) and predicted 30-s leg work capacity {right) In Immunocal (open bars) and control group (filled bars). Error bars. SE. Immunocal group was significantly dlfTerent from baseline (P < 0.01) and from control group (P < 0.02) lor lymphocyte GSH levels. Immunocal group was significantly different from basel。