醋酸地塞米松和硝酸咪康唑的配伍情况分析大论文.doc

醋酸地塞米松和硝酸咪康唑的配伍情况分析^p 大论文 - 吉林化工学院学士学位毕业论文 摘 要 复方醋酸地塞米松乳膏具有抗炎、抗变态反响及止痒作用，消炎快，止痒迅速,抗过敏作用强硝酸咪康唑为广谱抗真菌药，对皮真菌、念珠菌、醇母菌及其它藻类、子囊菌、隐球菌等具有抑制和杀灭作用，对革兰氏阳性球菌和杆菌也有很强的抗菌力采用紫外分光光度法测定复方醋酸地塞米松乳膏中醋酸地塞米松含量，制备硝酸咪康唑标准曲线将硝酸咪康唑对照品按不同比例参加复方醋酸地塞米松乳膏中，在常温下测定吸光度，选择醋酸地塞米松含量状况最正确的配伍比例，在0℃、10℃、20℃、30℃下，分别在1h、2h、3h、4h测定配伍后的吸光度变化，考察温度和时间对醋酸地塞米松含量的影响结果醋酸地塞米松含量平均值为0.7506mg/g,RSD为0.28%，醋酸地塞米松吸光度随配伍温度升高而增加，在配伍后3h醋酸地塞米松和硝酸咪康唑的吸光度根本不变 【关键词】：^p ：醋酸地塞米松 硝酸咪康唑 配伍 吉林化工学院学士学位毕业论文 Abstract pound dexamethasone acetate cream has anti-inflammatory, anti-allergic and antipru- ritic effect, anti-inflammatory faster Anti-pruritic rapid, strong anti-allergic effect. For broad- spectrum antifungal agents miconazole nitrate on the skin fungi, Candida albicans, bacteria and other alcohol mother algae, asycetes, Cryptococcus, such as the role of suppression and kil- ling of Gram-positive cocci and bacilli have a strong anti-bacterial power. UV Spectrophotome- tric Determination of dexamethasone acetate pound dexamethasone acetate cream content, preparation of miconazole nitrate standard curve. Miconazole nitrate reference substance by ad- ding different proportions of pound dexamethasone acetate cream, at room temperature, ab- sorbance measured, dexamethasone acetate content to choose the best bination ratio of the situation in the 0℃,10℃,20℃,30℃, the difference in the 1h, 2h, 3h, 4h after the determination of patibility of the absorbance changes in temperature and time on study dexamethasone acetate content. Dexamethasone acetate content of the results of the average of 0.7506mg / g, RSD 0.28%, dexamethasone acetate absorption bined with the temperature increase in the bined dexamethasone acetate after 3h and the Miconazole Nitrate absorbance will remain basically unchanged. Keywords: dexamethasone acetate miconazole nitrate patibility 吉林化工学院学士学位毕业论文 目 录 摘 要 ........................................................... I ABSTRACT ........................................................ II 1 绪论 .......................................................... 1 1.1 课题背景 ................................................... 1 1.2 国内外研究情况 ............................................. 1 1.3 主要研究内容 ............................................... 4 2 实验材料与内容 ................................................ 5 2.1 实验材料 ................................................... 5 2.1.1 主要仪器与实验用品 .................................... 5 2.1.2 药品与试剂 ............................................ 5 2.2 醋酸地塞米松含量测定 ....................................... 6 2.2.1 对照品溶液制备 ........................................ 6 2.2.2 供试品溶液制备 ........................................ 6 2.2.3 波长选择 .............................................. 6 2.2.4 工作曲线制备 .......................................... 6 2.2.5 重复性实验 ............................................ 6 2.2.6 稳定性实验 ............................................ 6 2.2.7 样品含量测定 .......................................... 6 2.2.8 回收率实验 ............................................ 7 2.3 硝酸咪康唑标准曲线制备 ..................................... 7 吉林化工学院学士学位毕业论文 2.3.1 吸收波长选择 .......................................... 7 2.3.2 标准曲线制备 .......................................... 7 2.4 醋酸地塞米松和硝酸咪康唑配伍 ................................ 7 2.4.1 配伍后醋酸地塞米松波长选择 ............................ 7 2.4.2 配伍后硝酸咪康唑波长选择 .............................. 7 2.4.3 配伍后最正确比例选择 .................................... 8 2.4.5 考察配伍温度和配伍时间对配伍后含量的影响 .............. 8 3 实验结果与分析^p ................................................ 9 3.1 醋酸地塞米松含量测定的结果与分析^p ............................ 9 3.1.1 标准曲线的制备结果与分析^p .............................. 9 3.1.2 重复性结果与分析^p ...................................... 9 3.1.3 稳定性实验结果分析^p .................................... 9 3.1.4 样品含量测定验结果分析^p ............................... 10 3.1.5 回收率实验结果分析^p ................................... 10 3.2 硝酸咪康唑曲线制备 ........................................ 10 3.2.1 标准曲线的制备结果与分析^p ............................. 10 3.3 醋酸地塞米松和硝酸咪康唑配伍结果与分析^p ..................... 11 3.3.1 配伍后醋酸地塞米松波长选择 ........................... 12 3.3.2 配伍后硝酸咪康唑波长选择 ............................. 11 3.3.3 配伍后醋酸地塞米松和硝酸咪康唑的配伍比例选择 ......... 13 3.3.4 考察配伍温度和配伍时间对配伍状况的影响 ............... 13 讨 论 .......................................................... 15 结 论 .......................................................... 19 吉林化工学院学士学位毕业论文 致 谢 .......................................................... 20 【参考文献】：^p ........................................................ 21 附录A .......................................................... 23 附录B .......................................................... 24 第 页 共 页。