GEO数据库的使用.docx

GEO数据库的使用（一）1、GEO数据库介绍GEO全称GENE EXPRESSION OMNIBUS,由美国国立生物技术信息中心NCBI创建并维护的基因 表达数据库创建于2000年，收录世界各国研究机构提交的高通量基因表达数据GEO上有四类数据GSM, GSE, GDS, GPLGSM是单个样本的实验数据1. GDS是人工整理好的关于某个话题的GSM的集合，一个GDS中的GSM的平台是一样的GSE是一个实验项目中的多个芯片实验，可能使用多个平台2. GPL 是芯片的平台,ill Affyrnetrix, Aglent 等 网址入口： http://www. ncbi. nlm. nih. gov/geo 2、GEO数据下载例如：我想找胃癌相关的疾病资料、研究文献，那么可以直接搜索gastric carcinoma% NCBI Reeouroet® How lb©GEO Home Documentation ■ Query & Browse ■ Email GEOGene Expression OmnibusG€O ts a publk: functkxwi gefxxmcs data repository si4)pcrt)ng MlAME compiiamt data submiMkxu Anay- and sequence-data are oooepted. Tools are prodded to help users query and download MpermenU and curaeed gene expreeaicn profllee.Gene Expression OmnibusG€O ts a publk: functkxwi gefxxmcs data repository si4)pcrt)ng MlAME compiiamt data submiMkxu Anay- and sequence-data are oooepted. Tools are prodded to help users query and download MpermenU and curaeed gene expreeaicn profllee.Getting StartedOwwwwFAQAbout GEO DawS«tsAbout GEO ProfilesAt)outGE02R AnalyseHow to Construct a QuofyHow to Download DataInformation for Submitterslogin io SubmitToolsS«arct)for 知Oos at GEO (XataSotsSearcti for Gene Expcession at G€O ProGtesS trastuzumab dWWS in peM«it dehved xenogra^ model.S«nd to： ■ Fliurs: Mo2<» FHlmOrvanom：Homo sap*eo«TjpeExpressen pcofing by arrayPtomxm GPL21185 12 SampieiDownload data: TXTSers ACCM5 GSE121767 O 200121787Anirvm GEO2RSearch details(Csgchp Fields]) AXD carcinoM(An Fields])> .\XD vH<«o sapienfi* (portn]Off(Subrnffier suppM) Gastric canoer b one of the meet common cancers wodchwde. Epftteirv-Bdrr vm- associeM gastric cancer accounts tor approaimatefy 10% V ell gastric cancers EBV sps* ns own protens and mRNAs |BART rn代MAs) and reguiales host gene expeession. In tib studx，we examined the effect oC EBV iniecoon on boat mRNA expeesson Dfflecentiai gene expeesson was analyzed be-Mwn EBV- noQabvo human gastric cancsr c«ll kw AGS and EBV posttrv* human gastric cancer cell line AGS-EBV. Organ^mHomo aapien*TypeExpressen profing 5 arrayPtotfOcm OR.6106 10 S>myy significance. Full UvstruBonsGEO accessionGSE121787■ S>mpSGroup Accewoo ■ V• Source name■ DMne groups Enter a Qroup nameSet TUmor reqlon-specinc rmcroaanalysis dccordlng to trastuzumab diwitxjtlon In breast cancer patient derived xenopraft• Gender scxrcc , TissueCoMrrwGSMM460WGSW5446OCOGSM3446061GSM3446062GSM3446063GS。