常用药物动力学参数.docx

八、常用药物的药代动力学参数参考表药物名称消除速率常数 k 或 0(hr-1)半衰期tl/2或 tl/20口服吸 收(％)表现分布容积vb(mg/L)有效血浓度范围(mg/L)峰时tm(hr)蛋白结合率 BP(%)消除率Cls[L/(hr.kg)]解离指数pKa乙基西梭霉素Nctilmicin0.3122.230.25-0.34-80.5-1.0(IM)0.78乙氧萘青霉素Nafillin1.390.500.280.5-1.0(IM)900.392.6(-COO-)乙胺丁醇Ethambutol0.1983.5301.871-102-4(PO400.37乙琥胺Ethosuximide成人50 —60儿童30—50100成人0.62儿童0.6940-1002-4(PO<2成人0.01 -0.013 儿 童 0.0161.3乙酰唑胺Acetazolamide0.1694.12.4-5.8>900.210-10.510-150.0347.29.0乙酰普鲁 卡因胺Ac etylprocai namide0.0828.5851.52-20100.12二甲胺四环素Minocycline12900.430.5-3.01-3(PO750.025二性霉素B AmphotericinB0.02918-24<30.5-1.0>900.025二氮嗪Diazoxid21-361000.290-950.005丁胺卡那霉素Amikacin0.2830.3112-390 — 1000.2510-251.0(IM)0-200.069三氯乙醇Trichloret4-80.60.5(PO400.07hanol碘甲腺氯酸钠t33390 — 10070-1601-299.50.014万古霉素Vancomycin0.126-80.470.2(IV)100.047土霉素Cxytetracycline0.0696-960—801.91.0-10.01-3(PO)20-300.18双异丙毗胺 Dicopy ramide0.1544.5-770 — 1000.8-1.9总药浓度2—5游离药浓度0.5-20.5-310-80（与 血药浓度 有关）0.00150.0048.34双氯青霉素 Dicloxacillin0.990.5-0.90.2915-181.0(IM)960.29水合氯醛Choral H ydrate4-80.6100.5(PO)400.07心得静Pondolol3-41002.00.05-0.151-30.4普蔡洛尔（心得安）Porpranlolo3>902.0-4.60.01-0.21-1.5(PO)90—950.79.5心得怡Sotalol5-1380—900.70.5-42-30.0549.8心得舒Alprenolol3>903.30.03-0.10.5-1.0(PO)850.769.7对乙酰氨基酚Paracetamol2-485 — 1000.8-1.01-100.5-1.0(PO)250.21扑米酮Primidone成人6—8儿童5—880—900.66-152-4(PO20—30单独用药0.0309合并用药0.0739去甲丙咪嗪 Desipramine10—2628—600.15-0.32-8(PO901.6910.2去甲金霉素 Demet0.07-0.04310 — 1660—801—20.5-31-4(PO500.08hylchlorte tracycline去甲替林Nortrpytli ne2760200.05-0.164-9(PO)92—960.5丙咪嗪Imipramine8-1680-10020-400.15-0.50.5 —1.0(PO)951.739.5丙基硫氧 嘧啶Prop ylthiourac il2-4800.2-0.41.0(PO)750.078.3丙磺舒Probenecid6-181000.12-0.18100-2001-5(PO)85-950.013.4布洛芬Brufen20.150.5-1.5(PO)990.052左旋多巴Leayodopa320-30(吸收)0.5-48.2白霉素Leucomycin0.1394.5 —5.52(PO)72苷珀酸Carbenoxoln e13 — 160.11-2(空腹PO)饭后(PO)0.005甲硝唑Metronidazole6—1490-1000.6-0.75-201-2(PO)5-200.045可待因Codeine0.2312—4503.450.0251.0(PO)0.88.2戊巴比妥Pentobarbital21—4270-800.71-4初次用药6 —18 长期用药3760-700.0158.1卡马西平Carbama zepine成人10 —30儿童8—1990-1000.8-1.44-121.0—2.0(IM)65-85成人初次用药0.011-0.026儿童初次用药0.028卡那霉素Kanamyci0.2890.332-2.590-950.252-80.5-1.0(IM)1.0(P00.0777.2nO)头抱氨苄（先锋霉 素IV） Ce phalexin0.6550.83-1.290-950.26G(+)0.5-3G(-)1.0-1215min(IV)0.5-1.0(IM)10-150.185.3(-COOH-)7.3 (-NH』头抱匹林 （先锋霉 素W） Ce phapirin.1.1550.690-950.23G(+)0.5-3G(-)1.0-1240-500.27头抱娄利 定（先锋II） Cephaloridine0.621-1.590-950.25同上同上2010-300.14头抱噻吩（先锋霉 素 I） Cep halothin1.40.5-1.090-950.25同上同上6560-800.23头抱格来 星（先锋 霉素III） C enhalogly cin0.770.980-95G(+)0.5-3G01.0-1215min(IV)0.5-1.0IM244.7头抱唑啉（先锋霉 素 V） Ce pahzolin0.3851.4-2.290-950.15同上5.0-1.0(lM)5min(PO)75-850.0582.3头抱雷定 （先锋霉 素科）Ce pahzolin0.8090.99440-50min90-950.25同上1.0(PO)5 min(IV)5-200.23头抱曲(先锋W) Cephacetrile0.4621.590-950.27G(+)0.5-3G(-)1.0-121.0(PO)5 min(IV)22.340.1251.97甲状腺素Thyroxine144-16890-950.1-0.20.03-0.0499.950.067甲氧苄胺 嘧定Trim ethoprim0.078-1220.5-121.5-3.3(PO)140.147.2甲氧苯青霉素Methicillin1.3860.5-100.3-0.421-0.5(IM)5035-600.332.7甲基多巴Methyldopa0.3520.5>24(PO)0-200.172.2(-COOH)10.6 (-NH)12.0(-OH)甲基多粘菌素0.1544050.51—2 (IM)0.077甲烯土霉 素 Methac ycline0.053310-1660-680.971.0-10.01—4(PO)—3(PO)700.052甲苯磺丁脲 Tobutamide4-885-1000.1-0.1550-100980.0145.3对基水杨 酸 Para a minosalic ylic acid0.770.9Sol:100混液：70 片:900.230.6Na:盐 0.5-1.0酸型3-4(PO)650.181.8(-NH)3.6(-COOH)四环素Tetracycline0.0996-1060-801-21.0-10.01-3(PO)25-300.138.3地高辛Digoxin0.01730-5050-936-100.0006-0.00181-2(PO)0.5-0.75250.14西梭霉素Sisomicin0.3050.3472.0-2.50.25 — 0.34-80.75-1.0(IM)0-200.85灰黄霉素Griseofulyin。