中药天麻治疗阿尔茨海默病的潜力.doc

Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer’s diseaseGuang-Biao Huang1, Tong Zhao1, Sushma Shrestha Muna1, Hong-Mei Jin1, Jong-Il Park1, Kyu-Sik Jo2, Bo-Hee Lee2, Soo-Wan Chae3, Sun-Young Kim3, Soo-Hyun Park3, Eun-Ock Park3, Eun-Kyung Choi3, Young-Chul Chung1, 41 Department of Psychiatry, Chonbuk National University Medical School, Jeonju 561-756, Republic of Korea2 Muju Chunma Native Local Industrial Center, Muju 568-844, Republic of Korea3 Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju 561-756, Republic of Korea4 Department of Pharmacology, Chonbuk National University Medical School, Jeonju 561-756, Republic of Korea5 Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju 561-756, Republic of Korea摘要摘要 研究证实，中草药天麻可减少淀粉样 beta 蛋白诱导的细胞凋亡。

为研究天麻对阿尔茨海默 病的可能治疗作用，我们将淀粉样 beta 蛋白 25-35 注射于大鼠双侧海马，建立阿尔茨海默 病大鼠模型，然后连续 52d 每日灌胃 500 或 1000mg/kg 天麻治疗结束后，Morris 水迷宫 试验评估显示阿尔茨海默病大鼠空间记忆功能明显改善，刚果红染色显示阿尔茨海默病大 鼠海马淀粉样沉积明显减少，Western blotting 和 Ellman 法检测显示阿尔茨海默病大鼠额前 皮质、内侧隔核和海马胆碱乙酰基转移酶表达上升，乙酰胆碱酯酶活性明显下降说明长 期应用天麻治疗阿尔茨海默病是很有改善症状潜力的方法关键词：关键词： 神经再生； 中医药； 天麻； 阿尔茨海默病； 老年痴呆； 水迷宫试验； 胆碱乙酰基转移酶； 乙酰胆碱酯酶； 基金资助文章； Acceptance date: 2012-11-06 Cite this article:Guang-Biao Huang, Tong Zhao, Sushma Shrestha Muna, Hong-Mei Jin, Jong-Il Park, Kyu-Sik Jo, Bo-Hee Lee, Soo-Wan Chae, Sun-Young Kim, Soo-Hyun Park, Eun-Ock Park, Eun-Kyung Choi, Young-Chul . Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer’s disease[J]. Neural Regeneration Research, 2013, 8(12): 1061-1070. 。