老年与中青年肾移植患者环孢素A血药浓度比较分析.pdf
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762# China Pharmacy 2005 Vol. 16 No. 10ÏS0\2005 M»16 »10 ùö50=,«V bùîZ_:"50Ð bÈÅ: 029- 85323243老年与中青年肾移植患者环孢素A血药浓度比较分析董卫华,董亚琳,王茂义,张华安(西安交通大学第一医院,西安市 710061)Ïms Ë|R96911;R97915ÓDSMAÓcI|1001- 0408( 2005)10- 0762- 03K1目的:探讨老年肾移植患者环孢素A( CsA)血药浓度的特点及临床意义 b方法:查阅242例肾移植患者病历资料及移植后CsA 血药浓度监测值,根据年龄分为中青年组( 18a~ 60a,218例)及老年组(> 60a, 24例),比较不同时期2组患者的血药浓度值 b结果:在口服CsA剂量接近的情况下,术后 60a, 24 cases) according to their age, the blood concentrations of the 2 groups indifferent time were compared1RESULTS: Under the circumstance of close oral dosage of CsA, the blood concentration of CsAin the older- aged group were found remarkably higher than that in the young & middle- aged group( P 80%¥1 p b0îÐt 1/ 21SÓD[4]¡( 417h~ 711h){É, V ?Ð ¦Õµ1 b4 gSÁ#É gd *¦Â ˪, 2ÕÅ4¥ö10îÐA UC 0~ t aA UC 0 ~ ] aC maxÜЪÉk¥Zµs,Å4W aÛ ùWíd9еs( P> 0105) ,ñ8Wµsµd9Ðil(Pçm1 Í -F93¡ÍÏ¥¨[J] 1江西医药, 1996, 31(2) : 1181[ 3] Ptacek P,M acek J,Klima J1 Determination of finaste_ride in human plasma by liquid- liquid extraction andhigh- performance liquid chromatography[ J]1 J Chro_matogr B Biomed Sci App l,2000, 738( 2): 3051[ 4] Steiner JF1 Clinical pharmacokinetics and pharmacod_ynemics of finasteride[ J] 1 Clin Pharmacokinet, 1996,30(1): 161(là ° ù: 2004- 07- 09©í ° ù: 2005- 01- 22)ÏS0\2005 M»16 »10 ùChina Pharmacy 2005 Vol. 16 No. 10 # 763#V1 2FÑBî'1 (x ? s)Tab 1 Comparison of general clinical data between 2groups(x ? s)FY è(n) 3(n) o( n) M-( a)8×( kg)º MF24 16 8 62100? 3106 63121? 101 83Ï ] MF218 148 70 38183? 9161 561 58? 81 73V2 º MFÐÏ ] MFª* ùCsA Ü (Ó0 i1 (x ? s)Tab2 ComparisonofaveragebloodconcentrationsofCsAinearlierperiodofpost- operationbetweentheolder- agedgroupandtheyoungandmiddle- agedgroup(x ? s)ªHW(wk)º MFÏ ] MFPCsA4(mg/( kg # d) )CsAÓ0 i( Lg/L )CsA4(mg/( kg # d) )CsAÓ0 i(Lg/L)1 4119? 1156 251138? 46173(n= 11) 4159? 0194 207156? 135130( n= 107) 01051y~ 2y 225126? 82155(n= 13) 190141? 70175(n= 115) 2y / 168130? 57182(n= 80) ÐBHWÓ0 i1 : P 60a¥/M±B¹ º MF, 18a~60a¥/M±B¹Ï ] MF,1" M/M±Ñ( 3moÄ1mo~ 2moS©1Q b114d9ÐZE9'¨t_,9'¨X 2_ b2²T211ª* ùÓ0 i1 ª* ùCsAÓ0 iS©²TWnV2 b®V2 Vn, º MF/M±ª6wk =òÛWCsA iíA÷µs(P> 0105),4WgíA÷µs( P> 0105) bÏ ] MF"»1wkл2wkÓ0 iµA÷µs, ÅòÛWíA÷µs b gCsA4¤Í¥ f /( 2FW4Üt_, P> 0105), º MFª -5wk¥Ó0 iA÷Ú¿Ï ] MF(P 0105) b º MFÐÏ ] MFòM]H ùÉ1 , 0105), O ¯1Ï ] MFÚ bº MF < 1mo a1mo~ 3mo a3mo~ 6mo a1y~ 2y4ñHW=, CsA i (Ú¿Ï ] MF( P< 0101P< 0105) b^®¿CsAö1 É#®P450½"},7P450½"ñ8µsv b®¿ º MÑÉ%½ê,É%h,Ê5Û¶8»M,ÉÓ@h,É#ÏP450½/,PCsA}®,0þ^ 8 =¹,ÁÓAÏCsA i9F, O^ Q?3 b7 6mo~ 12moHW=, º MFÐÏ ] MFÓ0 iíA÷µs, V ?Ð"'µ1 b بçf]Å4 ?4ÚM±rT,7TûS©CsAÓ0 i^ ب0þ¥$ b º MÑ¥3 Ø+Ä,'0þ}¤ açfÿ ?®/ a sQ?3qM ® aÉå]?3q Ú,# º MÑ÷F
