NCCN 食管癌化疗指南.doc

术前化疗：[1]紫杉醇和卡铂紫杉醇paclitaxel卡铂carboplatinAUC浓度时间曲线下面积Paclitaxel50mg^m2IVanDay1CartwplatlnAUC2IVonDay1Weeklyfor5weeks213[2]顺铂和氟嘧啶Cisplatin顺铂Fluropyrimidine氟嘧啶Capecitabine卡培他滨5-FU：5氟尿嘧啶PO：口服BID:—日2次Infusion：输液C冷dlatiriamdfluoFouyrimidiri巳Cisplatin75-100mg/mzIVonDays1and295-FU750-1000mg/mzIVcontinuousinfusionover24hoursdailyonDays1-4and29-3235-Dayeycls]紫杉烷+氟嘧啶Cisplatin30mg/m2IVonDay1Cdp&citabin«800mg/m2P0BIDonDays1-5W&ekl/lor5weeksCisplatin15mg/m2IVdailyonDays1-55*FUSOOmg7maIVcontinuousInfusionover24hoursdailyonDays1-5Cycledevery21day&for2cycles6奥沙利铂+氟嘧啶OxEliplPtinmicifluoropyrimidinieOxaliplatin45mg/mzIVonDay1weeklyfor5weeks5-FU225mg/m2IVcontinuousinfusionover24hoursdailyonDays1-33rOxaliplatin85mg/m2IVonDays1,15(and29for3doses5-FU180mg/m2IVdailyonDays1-33&Oxaliplatin85mg/mzIVonDays1f15,and29for3dosesCapecitabine625mg/m2POBIDonDay&1-5for5Tax向ne刍“日fluOKHiyrimidinePaclitaxel45-50mg/m2IVonDay1Capecitabine625-&2Sm^/mzPOBIDonDays1-5Weeklyfor5weeks13*14Docetaxel20mg/m2IVonDay15-FU200-300mg/m2IVdailyonDays1-5Weeklyfor5weeks15f16Dacetaxell20mg/m2IVonDay1Cap&citabine€25-325mg/m2POBIDonDays1-5Weeklyfor5[5]奥沙利铂+紫杉萜+卡培他滨Ox日liplatirycIouEnxeI,ardump音匸itabin巳Oxaliplatin40mg/m2IVonDays1,&15T22,and29Docetaxel20mg/m2IVonDays1,&15,22,and29Capecitabine1000mgfm2POBIDonDays1-7,15-21aand29-35Givenfor1cycle16围手术期化疗：Epirubicin：阿表比星Preoperative:术前Postoperative:术后PERIOPERATIVECHEMOTHERAPY(INCLUDINGEGJUNCTION)EQFfmDimbicin*cisplatin"and5*FU]Epirubicin&Dmg/m2IVanDayiCisplatin60mg/m1IVonDay15*FU2GQmg/m^IVconUnuousinfusionaver24hoursdailyonDays1*21Cydedevery21daysfor3cyclespireoperativelyand3cycl-espestoperatively17ECFmdclific^tion^Epirubicin&0mg/m2IVcnDay1Oxaliplatin130mg/m2IVonDay15*FU2GQmg/m5IVcontinuousinfusionover24hoursdailyonDays1*21Cydedevery21daysfor3cyclespireoperativelyand3cyclespestoperatively1EpirubicinSDmg/m2IVonDay1Cisplatin60mg/m2IVonDay1Capecitabine6^5mg/m2POB-IDonDays1^21Cydedevery21daysfor3cyclespireoperativelyand3cycl-espastepenatively1aEpirubicin50mg/m2IVonDay1Ox-aliplatin130mg/m2IVonD-ay1Capeeitabine625mg/m2POB-IDonDays1*21Cydledevery21daysfor3cyclespireoperativelyand3cyclespcstcperatively1s序贯化疗及外科放化疗Irinotecan:伊立替康Radiation:放疗SEQUENTIALCHEMiaTHERAPYANDCHE册ORADUkTIOM(SURGIfAL)Paclitaxel50mg/m5IVonDay1Cisplatin3(>mg/m2IVonQay1Weeklywithradialionfor&weekspreoperative,thenPaclitax&l175mg/mzIVanDay1Cisplatin?Smg/m^IVonDay1Cycledevery21daysfor3eyelegpostoperative19Preoperativedocetaxel75mg/m2IVonDay1Cisplatin75mgZm2IVonDay1Cycledevery21daysfor2cyclesFollowedbyDocetaxel20mgfrn2IVonDays仏&佩22,and29CisplatiinIVonDay1,S,46,2乙and20Givenfor!cyclewithradiation22Cisplatin30mgfm£fVonDays1,9,22,29Irinotecan5ftmg/kn2IVonDays1,8,22,29Withradiadonpreop&rative,thenCisplatin30mg/m^lVonDays1and3Irinotecan65mg/m5IVonDays1and3Cycledevery21daysfor3cyclespostoperative19PrecperativeGisplatin30mg/m2IVonDays1and3Irinotecan65mg/m2IVonDays1and8Cycled*very21daysf*r2eytlesFollowedbyCisplatin3Gmg/mzIVIrinotecan65mg/m2IVGivenwithradiationDays1,S,15,22orDays19H,22,andPreoperativecisplatin2Cmgrm2IVonDays1*5fi^FU200rrg/m2IVGantinuausinfusionover24hoursdailyonClays1-21Cycledevery23daysfor2cyclesFollowedbyPaclitaxel45mgfrn5IVonDay15-FU3DOrrg^m2IVcontinuousinfusionover24heursdailyonDays1*5Weeklyfor5weekswithradiation13非外科治疗化疗方案Leukovorin:甲酰四氢叶酸,抗贫血药CisplatinandfluorQDYriEiTinECisplatin75-100mg/m£IVonDay15-FU7S0-1000mg/m2IVcontinuousinfusionover24hoursdailyonDays1-4Cycledevery28daysfor2-4cyclesfor2cycleswithradiationfollowedby2匚yulESwithoutradiation51Cisplatin30mg/m3IVonDay1Capeciiabiine300mg/ni3POBIDonDays1'5We&klyfor5weeks*OxaliplatinandfluaropyrimidineOxaliplatin46-50IVonDay1weeklyfor6weeks5-FU225mgfIVcontinucusinfusionaver24hoursdailyonDays1-337OxaliplatinBSmg/m2IVonDays1h15,and29for3donsS-FU1B0mg/nn^IVdailyonDays1-33&OxaliplatinB5rngTrn^lVonDays1h15,and29for3doses.Capecitabine625rmg/m5POBIDonDays1-5far5weeks5Ox-aliplatin85mgfm2IVonDay1Leucovorin4fl-0mg/mzIVonDay1S-FU400mg/nn^IVPonDay15-FU6C0mg/nn£IVcorttirtucusinfusicnover24hoursdailyonDays1and2Cycl&devery14daysfor3cycleswithradiationfallowedby3cycleswithoutradiaticni4Taxmnm且口曲cisplatinPaclitaKel60mg/rr2IVonDays1,8f15,and22Cisplatin75mg/miIVonDay1Givenior1cycle10Docetaxel60mg/m3IVanDays1and22CisplatinGMOmg/m2IVonDays1and22GivenffprlcycleIrinotecan&5mg/m2IVonDays1,8r22,29Cisplatin30mg/m2IVonDays1,8h22,2912Docetaxsl20-30mg/rn2IVonDay1Cisplatin20-30mg/m2IVonDay1We&klyfor5weeksPaclitajcelandcarboplatinPaclitaxel50mg/m3IVonDay1CarboplatinAUC2IVonDay1WeeklyforSweeks3iFinotecanantjTaxarwandfluoropyrinnidiiiePaclitaxel45-50mg/m2IVonDay1Capecitabine625-825mg/m2POBIDonDays1-5Weeklyfor5weeks1Docetaxel20mg/m2IVonDay15-FU200-300mg/m2IVdailyonDays1-&Weeklyfor5weeks15-16Docetaxel20mg/m2IVonDay1Cap«citabin&625-825mg/m2POBIDonDays1-5Weeklyfor5weeks14*16Oxaliulatin,docQtaiCQl,andcaDecitabineOxaliplatin40mg/m2IVonDays1,8,15,22,and29Docetaxel20mg/m2I。