(完整word版)投稿信CoverLetter和Highlights模板.doc

模板1Dear Prof. XXXXX,      Here within enclosed is our paper for consideration to be published on “(Journal name)”. The further information about the paper is in the following:     The Title:     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX   The Authors:   XXXXXXXXXX   XXXXXXXXXXXX  and  XXXXXXXXXX    The authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere.   I am the corresponding author and my address and other information is as follows,                             Address:    Department of XXXXXXXXX,                           Tsinghua University,                           Beijing, 10084,                           P.R.China               E-mail:     XXXXX@                Tel:       86-10-62785001                 Fax:       86-10-62785001  Thank you very much for consideration!                                                   Sincerely Yours,                                                   Dr. XXXXXXXXXXX模板2Dear XX (Editor):Here is our paper submitted to "(XX Journal)".The Title:   XXXXThe Authors:   XXX  XXX  and  XXX In this paper, we ... The authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere. The corresponding author is Dr. XXX and his address and other information is as following:Address: Department of XXX, XX University, ..., P.R.ChinaE-mail: XXXXX@Tel: +86-xxx-xxxxxxxxFax: +86-xxx-xxxxxxxx Thank you very much for consideration!Sincerely Yours,Dr. xxx 模板3 Dear Mr. **We believe the paper may be of particular interest to the readers of your journal as it ........1. The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed.2. I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience. kind regards.Your sincerely,通讯作者Dear Prof. Gil:This is a manuscript by**and **entitled “.......”. It is submitted to be considered for publication as a “...” in your journal. This paper is new. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal.Correspondence should be addressed to **at the following address, phone and fax number, and email address:...Thanks very much for your attention to our paper.Sincerely yours,**  投稿信模版四（实例） Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also ha。