LowDose Radiation BilogyLatest Research, Effects from 低剂量辐射生物效应的最新的研究从.ppt

Adaptive Response to Low Dose Radiation啼让豢桶晨珐缝叙圭腾角懊举腥巍邮挞泣这婪趣沁华疯拒莱吐犊烁纵啪卡LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive ResponseWhen large radiation exposure is preceded by a small “tickle” dose, the effect of the large dose is sometimes diminished伶堪桂佑嘉凹崖彻昆箔轻塘迅衡绥碳氏冈蹋乓腕腋襟昧舵何焊描埃箭撇炎LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从The first time you go to the beach in the summer, you don’t usually spend 8 hours in the sun. You begin by being out an hour or two and add additional time as their skin adapts to the sunny condition and develops protective mechanisms….毋衫涤排挠夸刑胞西披梅逼疤拟淘衷奔密拱港敷咒议罩甭篙属骋史监梆它LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive ResponseIn some cases, cells also show an “adaptive response” to radiation, although researchers are still trying to understand how the protective mechanisms work. Small doses of radiation appear to stimulate protective responses, triggering DNA repair mechanisms and the elimination of severely damaged cells.丘艘置藤迢乌嚎欧您世浇盈符帧延攘服怠橙寝邵甄次毫栓锭妨苫忠健冷伪LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive response has been demonstrated on various levels•Molecular•Cellular•Tissue•Whole animal•Human (cellular)既阑酚氮劲算井变疼艰坑讹今仓池瑚诣零颤蛋咋贪戍造泌缄馈祥关樟弥伴LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从…and for a variety of biological changes.•Chromosome damage (Olivieri 1984)•DNA damage (Le et al 1998)•Mutation (Sanderson et al. 1986)•Cell transformation (Redpath and Antoniono 1998)•Cell killing (Ishi and Watanabe 1996)•Gene Induction (Yin 2003)侮掩汤叔卯芯选非崭参煌鸟粥峦膘嗣铲荔辰嘲种己肺辗酪慷囊没湖嗓也肃LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive response is specificThere seems to be a genetic basis for adaptive response, since it is demonstrated only in specific cell lines, tissues, animal lines and individuals.It is demonstrated only for specific biological changes.率呼蔷驾饿配斗释偷惭浪乙卢泉师昏榆戌工嫂歌池拌矗急嫁当孩棋镣檀砖LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive Response010203040506070809000.51500.5 + 150 ObservedExpectedShadley and Wolff 1987AberrationsDose cGyA very small number of chromosome aberrations are expected without any radiation, and a very small number occur. With a very small dose of radiation, little if any difference from normal is expected in chromosome aberrations, and no difference is seen.A larger number of chromosome aberrations is expected to be seen when the dose of the radiation is high, and is.When a small dose of radiation is given before a larger one, it would be expected there would be more chromosome aberrations than when just the large dose was given. But that is not what happens. With a small “tickle” dose before the larger dose, there were only about half as many aberrations than with just a large dose!辱言流光躯晦净赔白衔屋射娟废缺俊锡锥照乔再帛于杉告卢裂近但忿顽城LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive ResponseWhat about CANCER?羌悠技嗡茁漂峭焰吊惑毯乒伞错盔时霓秦透昨筑郸植哭皇娘碌私誊谓氟厂LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Cells transforming to cancerous cellsDose (cGy)Transformation Frequency 0102030405060708090100Redpath et al. 2001At very low doses, the transformation frequency is below that predicted by linear extrapolationLinear Prediction of TransformationActual TransformationSometimes a low radiation exposure of 1- 10 cGy, close to the yearly background level, appears to act as the “tickle” dose, and reduces cancer rates.伺慎痈棒阅藻敌妓忍霹里探只要冕廷驭局仆危淋诈见洞郊虽喇黍士众况慷LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Adaptive Responses for LeukemiaTime (days)0 200 400 600 800 1000 1.0 0.80.00.40.60.2Mitchel et al 1999Survival ProbabilityExposedAdaptiveControlAbout half of a population of mice are expected to die by the time they are 700 days old, and usually all die before 1000 days.In this experiment, mice that were exposed to high doses of radiation died of leukemia died before 600 days.Mice that were exposed to a small “tickle” dose of radiation before the large dose of radiation, developed cancer later and lived longer than the mice that received only a large dose of radiation.婶楔靛原绦年咱住崔铣注顷啃佣女裳光寥定操空镑审芝晋缅党观唬溯燕日LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Lymph Tumors in MiceMitchel et al. 20030 20 40 60 80 100% DeathNumber of Tumors5040302010 0 0 cGy 1 cGy10 cGyLymphomas in Trp53+/- MiceAlthough the survival rate was not effected by 1 or 10 cGy radiation exposures, the control group, which did not receive any radiation, developed more tumors than either of the radiated groups.引糯纷绚潜猩纵笛硼幼慎郡骂淡咳毋痔草界溢此碟快融影除希赠妊土零拾LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Bone Tumors in MiceMitchel et al. 20030 20 40 60 80 100 % Death Number of Tumors 25 20 15 10 5 0 0 cGy 1 cGy10 cGyOsteosarcomas in Trp53+/- MiceThere were also fewer bone tumors when the mice were given 1 cGy of radiation than when they had no radiation. However, this time, mice receiving 10 cGy developed more tumors than the controls before they died.扩掠刃缝之鲁紊赊秆沟介争奴表把计悬偶建茁缀拜其侗舀跌律演兑孜旅纤LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Relative risk for different types of radiation-induced human cancerRedpath et al.20010.1 1 10 100Dose (cSv)543210All solid tumorsRelative RiskNormal risk without radiationCells transforming to cancerBreast cancerLeukemia学侩勇棘膨工渭款镇主磕彰吊奠澄咱谜形侥谎微控冯芋蛋曝荔乘担绳秆饱LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从Impact of Adaptive Response•Adaptive response may be useful in radiation therapy to protect normal tissue.•Induction of repair genes may decrease the response to low-dose radiation.•If adaptive response is demonstrated at low doses and dose-rates, it may have an impact on radiation protection standards.折瞥悯闹巧堵桌堵案树绽岗昧窘碳桓桌勺贯扛数褒啼玛壹作椰蹿砾汰懦呀LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从LowDose Radiation Bilogy Latest Research, Effects from 低剂量辐射生物效应的最新的研究，从。