内科学急性白血病(英文)
94页1、leukemia,Leukemia,Definition: A group of malignant clonal malignant disease of hematopoietic tissue . Blockage of cell differentation in different stages. Accumulation of leukemic cells in bone marrow or other organs. Impaired production of normal blood cells.,Progenitor cell,Stem cell,Normobalst 原红,Basophilic normoblast 早幼红,Polychromatic normoblast 中幼红,Ortho-chromatic normoblast 晚幼红,Myeloblast 原粒,Promyelocyte 早幼粒,Myelocyte 中幼粒,Metamyelocyte 晚幼粒,band cell 杆状核,Segmented cell 分叶核,Monoblast 原单,Prom
2、onocyte幼单核,Monocyte 单核,Lymphoblast 原淋,Prolymphocyte 幼淋,Lymphocyte 成熟淋,Lymphocyte 成熟淋,Megakaryoblast 原巨核,Promegakaryocyte 幼巨核,Granular megakaryocyte 颗粒巨核,Platelate-forming megakaryocyte产板巨核,Category of Leukemia,Acute Lymphoblastic Leukemia(ALL) Acute Leukemia Acute Myeloid Leukemia(AML) Chronic Myeloid Leukemia(CML) Chronic Leukemia Chronic Lymphocytic Leukemia(CLL),Acute myelogenous leukemia (AML),Acute myelogenous leukemia (AML) is a clonal malignant disease of hematopoietic tissues that is cha
3、racterized by accumulation of abnormal leukemic blast cells, principally in the marrow and impaired production of normal blood cells. Thus, the leukemic cell infiltration in marrow is accompanied, nearly invariably, by anemia and thrombocytopenia. The absolute neutrophil count may be low or normal, depending on the total white cell count.,Incidence of AML,Age adjusted incidence 3.6 per 100,000. Median age at diagnosis: 66 years. Lifetime risk of a diagnosis of AML: 0.39% of people born now.,Nati
4、onal Cancer Institute.SEER Stat Sheets: Acute Myeloid Leukemia. http:/seer.cancer.gov/statfacts/html/amyl.html,Age distribution of AML,Age distribution of ALL,Incidence of Leukemia,In China: Acute Leukemia Chronic Leukemia Adult: AML ALL Children: ALL AML,Etiology of Leukemia,Virus: HTLV-I, HTLV-II, EB Ionizing Radiation: Atomic bomb exposure Chemical Agents: Benzene; cytotoxic drugs chloramphenicol(氯霉素); phenylbutazone(保泰松). Hereditary Factors: Down syndrome, 21trisomy(三体),ACUTE LEUKEMIA,FAB cl
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