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内科学胃炎(英文)
66页1、Gastritis,Definition,Gastritis A wide variety of inflammatory or hemorrhagic conditions of gastric mucosa: Damage Inflammation Regeneration Gastropathy Epithelial cell damage and regeneration without associated inflammation,Anatomical site,ANTRUM 胃窦,CARDIA 贲门,BODY 胃体,MUCOUS SECRETING ENDOCRINE,SPECIALISED SECRETORY PARIETAL ACID CHIEF - PEPSINOGEN ENDOCRINE: D cell:HISTAMINE Mastocyte:SOMATOSTATIN,MUCOUS SECRETING ENDOCRINE: GASTRIN,5 Hydroxyl Tryptamine,Gross histologic,Gastritis is mostly a hi
2、stological term that needs biopsy to be confirmed,Classification,Acute Gastritis,Chronic gastritis,Acute referring to short term inflammation Acute referring to neutrophilic infiltrate,-Chronic referring to long standing forms -Chronic referring to mononuclear cell infiltrate especially lymphocyte and macrophages,Acute Gastritis,Developing shortly exposure to various injurious substances or following depression in mucosal blood flow,Acute Gastritis,Erosive & Hemorrhagic gastritis Helicobacter py
3、lori-induced gastritis Infectious gastritis (excluding H. pylori),Etiology and Pathogenesis Stress Shock ; Sepsis ; Burn; CNS Trauma or Surgery Renal, Hepatic or Respiratory Failure Chemical injury NSAIDs Alcohol Bacteria and Toxin (Helicobacter pylori),Mucosa ischemia ; thromboxane A2 , leukotriene C4 Inhibition of epithelial renewal ; Impairment of gastric mucosa barrier ; Hydrogen ion back-diffusion ; Free radicals,Stress Related Gastric Mucosa Damage,NSAIDs and Gastritis Inhibiting synthesis
4、 of prostaglandins by inhibiting cyclooxygenase (COX, 环氧合酶),Chemical injury,Alcohol and Gastritis Alcohol is lipid-soluble High concentration of ethanol transverses gastric mucosa and results in mucosa damage,Chemical injury,Clinical Manifestations Acute Erosive Occult Blood in Stool,Clinical Manifestations,Epigastric Pain or discomfort Anorexia Nausea and Vomiting,Definite Diagnosis: Emergency Endoscopy,Mucosal congestion, oedema, inflammation & ulceration,ACUTE GASTRITIS - MORPHOLOGY,Two Speci
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