临床血液学检验技术骨髓增殖性肿瘤
130页1、Myeloproliferative neoplasms, (MPN) 骨髓增殖性肿瘤,OVERVIEW Myeloproliferative neoplasms (MPN) and myelodysplastic syndromes are diseases in which the bone marrow makes too many red blood cells, platelets, or certain white blood cells. Myelodysplastic syndromes are a group of cancers in which immature blood cells in the bone marrow do not mature or become healthy blood cells.,OVERVIEW,MPN are diseases that have features of both myelodysplastic syndromes and myeloproliferative neoplasms. Certain types M
2、PN may become a type of blood cancer called acute leukemia,Classification,Chronic myelogenous leukemia, BCR-ABL1+ Polycythemia vera, PV Essential thrombocythemia, ET Primary myelofibrosis, PMF Chronic eosinophilic leukemia, not otherwise specified, CEL,NOS Chronic neutrophilic leukemia mastocytosis,Chronic myelogenous leukemia, BCR-ABL1+,CML is characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.
3、 CML is a slowly progressing blood and bone marrow disease that usually occurs during or after middle age, and rarely occurs in children.,CML is a clonal malignancies of the hematopoietic stem cell. The proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding.,Myelogram,Hemogram,Cytogenetic marker,Ph chromosome: CML is associated with a characteristic chromosomal translocation called the Philadelphia chromosome.,Causes,The initiating
4、 factor of CML is still unknown. But exposure to irradiation has been implicated. Other agents, such as benzene, are possible causes. Peak Incidence at ages 20 to 50 years old,clinical manifestation (Signs and symptoms),Patients are often asymptomatic at diagnosis. Presenting incidentally with an elevated white blood cell count on a routine laboratory test. In this setting, CML must be distinguished from a leukemoid reaction, which can have a similar appearance on a blood smear.,Symptoms of CML
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