调节性B细胞.ppt
31页1、Bregs RegulatoryBcells Introduction 1 CluestoBregsexistence 2 Developmentanddifferentiation 3 4 Contents PhenotypicalIdentification 6 Bregsindiseases FunctionofBregs 5 Introduction Traditionally BcellshavebeenthoughttocontributetodiseasethroughproductionofantibodiesInthepasttwodecades investigatorshaveattributedadditionalfunctionstoBcells includingantigenpresentation theproductionofmultiplecytokinesRecently theabilityofBcellstonegativelyregulatecellularimmuneresponsesandinflammationhasbeendescri
2、bedandtheconceptofregulatoryBcellshasemerged CluestoBregsexistence 2002 BcellssuppressDTH IL 10 producingBcellsregulateautoimmunityCD19 CD1dhiBcellsproducingIL 10controlTh2 drivencolitis theterm regulatoryBcells whichdefinesB cellsubsetswithregulatoryproperties wasfirstintroduced Bcell de cientmicedevelopchronicEAE Bcellscouldrestraintheseverityofautoimmunedisease 1980 antigen activatedBcellscouldinducetoleranceinrecipientnaivemice Supporta suppressiveframework forBcellsandintroducealinkwithT ce
3、lltolerance DevelopmentandDifferentiation 在骨髓发育 分布外周淋巴器官 参与特异性免疫 定位于大网膜 胸腔及肠黏膜固有层 参与非特异性免疫 DevelopmentandDifferentiation FOBcell T2 MZPBcell MZBcell LeBienTW TedderTF Blymphocytes howtheydevelopandfunction Blood 2008 DevelopmentandDifferentiation DevelopmentandDifferentiation MauriC EhrensteinMR The short historyofregulatoryBcells TrendsImmunol 2008 DevelopmentandDifferentiation MauriC EhrensteinMR The short historyofregulatoryBcells TrendsImmunol 2008 DevelopmentandDifferentiation MizoguchiA Bh
4、anAK AcaseforregulatoryBcells JImmunol 2006 PhenotypicalIdentification HeY TherolesofregulatoryBcellsincancer JImmunolRes 2014 PhenotypicalIdentification MauriC ImmuneregulatoryfunctionofBcells AnnuRevImmunol 2012 PhenotypicalIdentification MauriC ImmuneregulatoryfunctionofBcells AnnuRevImmunol 2012 PhenotypicalIdentification BodhankarS IL 10 producingB cellslimitCNSinflammationandinfarctvolumeinexperimentalstroke MetabBrainDis 2013 PhenotypicalIdentification Thereisnouniquemarker orsetofmarkers
5、 thatexclusivelyidentifiestheBregsThereisnomasterregulatortranscriptionfactoridentifiedinBregdevelopmentIL 10secretionisstillavitalstandardintheidentificationofBregs FunctionofBregs MizoguchiA BhanAK AcaseforregulatoryBcells JImmunol 2006 FunctionofBregs MauriC ImmuneregulatoryfunctionofBcells AnnuRevImmunol 2012 FunctionofBregs MauriC ImmuneregulatoryfunctionofBcells AnnuRevImmunol 2012 MauriC ImmuneregulatoryfunctionofBcells AnnuRevImmunol 2012 FunctionofBregs Bregsinautoimmunity Experimentala
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